Wednesday, March 26, 2014

Book Report/ Review: The Immortal Life of Henrietta Lacks by Rebecca Skloot

I was going through the files on my computer when I came across my book report/ review thing of THE IMMORTAL LIFE OF HENRIETTA LACKS by Rebecca Skloot.  I thought I'd share.  Even if you have no connection to AP biology, my opinion on the book is there.

The Immortal Life of Henrietta LacksThe Immortal Life of Henrietta Lacks by Rebecca Skloot

My rating: 5 of 5 stars
Current Goodreads Rating: 4.04

HeLa cells are of one of the most important cell lines used in research today.  They have aided in developing the polio vaccine and cancer treatment drugs like Taxol.  HeLa came from the cervical cancer cells of an African American woman named Henrietta Lacks.  She died over 60 years ago, but HeLa cells still live.  While she received her first radium treatment at Johns Hopkins, doctors took a sample of her tumor without her or her family knowing.  After scientists discovered that Lacks' cells replicated and hadn't died, they realized their value to research since they could be tested without harming animals or humans.  A billion dollar industry of producing, selling, and trading the cells soon precipitated.  Meanwhile, the surviving Lackes could not even afford health insurance.  They received none of the profits from their mother's cells, sparking debate about the ethics of using patients' bodily scraps for scientific advancement without consent.  HeLa has played a monumental role for science, but they wreaked havoc on the Lacks' family.  Years later, the family has never sued Johns Hopkins or any other doctors for stealing Lacks’ cells.  Their main focus is trying to make the world aware of the woman behind the famous cells.
               Inserting its DNA into one arm of her eleventh chromosome and turning off her p53 tumor suppressor gene, HPV caused Lacks' cancer.  There was a loss of cell cycle control, and the cancer cells divided rapidly and invaded other tissues.  These cells do not exhibit density-dependent inhibition or anchorage dependence.  She was diagnosed with epidermoid carcinoma of the cervix.  However, she was wrongly diagnosed.  Instead, her cancer's origin was glandular tissue rather than epithelial tissue.  This type of cancer metastasizes much faster than epidermoid carcinoma.  Yet, her syphilis may have also been a factor in the cancer's spreading, for it weakens the immune system.  Regardless of the cause, the cancer metastasized to other parts of Lacks' body, explaining why “her other organs were so covered in small white tumors it looked as if someone had filled her with pearls” at the time of her death (Skloot 118).  Ultimately, the cancer prevented other parts of her body from functioning.  Because tumors blocked her urethra, Lacks died from the buildup of toxins that should have been released through urine.
               Unlike normal somatic cells, Lacks’ cancerous cells were immortal because of her telomeres never shortening.  Normally, telomeres at the end of chromosomes shorten with each cellular division.  After they are almost gone, the cell stops dividing and dies.  Yet, HeLa contains an enzyme called telomerase that rebuilds telomeres, meaning that the cell is given more time before its death.  The presence of telomerase is the reason that HeLa is immortal.  Whenever cultured with other cells, HeLa always outlived them.  Because of their immortality, Lacks’ cells will always be an available resource for research and contribute to new discoveries.   
               Scientists are always careful to prevent cross contamination, but HeLa cells are able to float on dust particles or travel from lab to lab, riding on the scientists’ shoes.  If one HeLa lands in a culture dish, the HeLa cells could take over the entire dish.  Therefore, instead of conducting useful research, scientists may have simply regrown more HeLa.  Years of research and millions of dollars were wasted in addition to finding out that spontaneous transformation didn't exist, but rather cells were invaded by HeLa.  So, a promising possibility for finding a cure for cancer was then extinct, according to Dr. Gartler who came up with the HeLa contamination hypothesis.

3. In 1951, when doctors took a sample from Lacks without her permission, it wasn't illegal.  It still isn't illegal.  When tissues are a part of one's body, they are definitely his or hers.  However, when they are no longer a part of the body, as a removed mole or red blood cells from a blood test, they most likely get stored somewhere for future research.  Without these, testing for possible cures to diseases wouldn't be possible, but people have trouble accepting that their cells are used for purposes to which they are unaware.  They still feel a sense of ownership even though the cells are from parts of their tissues that they voluntarily gave.  Further complications arise when these cells have value like the HeLa cells.  Someone other than the owner of them makes money, and he or she gets nothing.  If people are aware that their cells are valuable, they can paten them, but most people are never told this information.  Evidently, the issues concerning ethics in The Immortal Life of Henrietta Lacks continue to be relevant and will probably pose more issues in the future as researching develops.
               Skloot touches upon all four of the big ideas studied in AP Biology in her book.  First, HeLa cells have evolved while growing in culture like they would in a human body.  Exposure to light, chemicals, and different environments causes the DNA to change which can be passed on to future generations of cells after cell division.  Though once containing the same DNA as Lacks, HeLa has evolved, leading to diverse DNA.  Yet, HeLa is still considered human.  Next, cancer cells can divide infinitely if continually supplied with nutrients.  They need an energy source and building blocks to grow and reproduce.  In search for nutrients and oxygen, the cancer may spread or generate its own blood supply.  Additionally, cells store and transfer DNA.  Specifically, doctors wanted blood samples from her children to compare to HeLa's in order to create a map of Lacks' genes to solve the contamination problem.  Theoretically, one half of her children's DNA would be from her and the other from their father.  Lastly, HeLa has biological systems that interact on a cellular level.  During mitosis, the mitotic spindle cooperates with the chromosomes; motor proteins walk the chromosomes along the microtubules to separate poles during anaphase and eventually form two daughter cells.

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